发明名称 |
HIV-PEPTIDE-CARRIER-CONJUGATES |
摘要 |
<p>The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.</p> |
申请公布号 |
EP1605972(A2) |
申请公布日期 |
2005.12.21 |
申请号 |
EP20040723204 |
申请日期 |
2004.03.25 |
申请人 |
CYTOS BIOTECHNOLOGY AG |
发明人 |
BACHMANN, MARTIN, F.;HUBER, ADRIAN;MANOLOVA, VANIA;MEIJERINK, EDWIN;PROBA, KARL, G.;TISSOT, ALAIN |
分类号 |
A61K39/00;A61K39/21;A61K39/39;C07K14/02;C07K14/025;C07K14/08;C07K14/47;C12N15/117;(IPC1-7):A61K39/39;C07K14/16;A61K39/12 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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