发明名称 |
PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS |
摘要 |
<p>The invention discloses an improved process for racemization of methyl (R)(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.</p> |
申请公布号 |
EP1606231(A1) |
申请公布日期 |
2005.12.21 |
申请号 |
EP20040705140 |
申请日期 |
2004.01.26 |
申请人 |
NADKARNI, SUNIL SADANAND;PATEL, HASMUKH MATHURBHAI |
发明人 |
NADKARNI, SUNIL SADANAND;PATEL, HASMUKH MATHURBHAI |
分类号 |
A61K9/20;A61K9/28;A61K9/48;A61K31/4365;A61P7/02;C07D495/04;(IPC1-7):C07B55/00;A61K31/436;C07B57/00 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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