发明名称 |
PARENTERAL FORMULATIONS OF PEPTIDES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS |
摘要 |
The subject invention provides a pharmaceutical composition comprising: an, aqueous carrier; from 0.1 mg/ml to 20 mg/ml of the composition of a pharmaceutically acceptable salt of a) peptide comprising at least 12 and at most 30 consecutive amino acids having a sequence corresponding to (i) a sequence of amino acids found within a complementarity-determining region (CDR) of a heavy or a light chain of a human monoclonal anti-DNA 16/6 Id antibody, or (ii) a sequence of amino acids found within a complementarity-determining region (CDR) of a heavy or a light chain of a pathogenic anti-DNA monoclonal antibody that induces a systemic lupus erythematosus (SLE)-like disease response in mice, or b) a peptide comprising consecutive amino acids having the sequence shown by any of SEQ ID NOS. 8-17, or c) a peptide comprising consecutive amino acids having a sequence of any of and b), or at least two of the sequences in (a)(1), (a) (ii) and (b)(i) through (b)(x), or d) a peptide comprising consecutive amino acids having a sequence comprising at least two identical sequences included in (a) (i), (a) (ii) and (b) (i) through (b)(x); and a solubility enhancer, wherein both the peptide and the solubility enhancer are dissolved in the aqueous carrier; and wherein the composition has a pH between 4 and 9, and a method of alleviating symptoms of SLE in a human by administering an effective amount of the composition. |
申请公布号 |
WO2004064787(A3) |
申请公布日期 |
2005.12.15 |
申请号 |
WO2004US00948 |
申请日期 |
2004.01.14 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD.;TEVA PHARMACEUTICALS USA, INC.;COHEN-VERED, SHARON;NAFTALI, ESMIRA;WEINSTEIN, VERA;GILBERT, ADRIAN;KLINGER, ETY |
发明人 |
COHEN-VERED, SHARON;NAFTALI, ESMIRA;WEINSTEIN, VERA;GILBERT, ADRIAN;KLINGER, ETY |
分类号 |
A61K;A61K6/00;A61K9/00;A61K9/19;A61K38/00;A61K38/08;A61K38/10;A61K38/16;A61K38/17;A61K39/395;A61K47/40;A61P37/00;C07K7/06;C07K7/08;C07K14/47 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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