MONOMETHYLPHYTOSPHINGOSINE AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME

摘要

Disclosed are a monomethylphytosphingosine (MMPS) or a pharmaceutically acceptable salt thereof and a composition containing the same. The compound can highly inhibit an activity of sphingosine kinase and thus interrupt many mechanisms caused by the sphingosine kinase. In particular, the invention prevents ceramide and sphingosine from being phosphorylated due to sphingosine kinase to maintain concentrations of ceramide and sphingosine to be high, thereby inducing apoptosis of a cancer cell and thus treating or preventing a cancer or a cancer-related disease. In addition, since the invention inhibits a cell proliferation-promoting activity of sphingosine kinase and thus can treat or prevent a hyper-proliferative disease such as cancer or psoriasis.