发明名称 |
Therapeutic compositions and methods for treating diseases that involve angiogenesis |
摘要 |
According to the present invention, S100A4 protein also known as Mts-1 interferes with the function of Annexin 2 and Annexin2/P11 tetramer by binding to Annexin 2. The present inventors have demonstrated that binding of S100A4 with Annaxin 2 modulates angiogenesis by interfering with Annexin 2 mediated tissue plasminogen activator (tPA) dependant conversion of plaminogen into plasmin and further conversion of plasmin into angiostatins. The present invention has further identified that the S100A4 protein binds to the N-terminal region of Annexin 2. Accordingly, the present invention discloses peptides and pharmaceutical compositions thereof and methods of treating cancers and other diseases that involve angiogenesis, by interfering with the interaction between S100A4 and Annexin
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申请公布号 |
US2005277575(A1) |
申请公布日期 |
2005.12.15 |
申请号 |
US20050087719 |
申请日期 |
2005.03.24 |
申请人 |
SEMOV ALEXANDRE;ONICHTCHENKO ANATOLI;IOURTCHENKO LUDMILA;OCHIETTI BENOIT;PIETRZYNSKI GRZEGORZ;ALAKHOV VALERY |
发明人 |
SEMOV ALEXANDRE;ONICHTCHENKO ANATOLI;IOURTCHENKO LUDMILA;OCHIETTI BENOIT;PIETRZYNSKI GRZEGORZ;ALAKHOV VALERY |
分类号 |
A61K31/7088;A61K38/00;A61K38/04;A61K38/08;A61K38/17;A61K47/10;A61K47/34;A61K47/42;A61K47/48;A61K48/00;C07K7/06;C07K19/00;C12N15/11;(IPC1-7):A61K38/17 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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