METHODS FOR DOSE SELECTION OF LIPOSOMAL ENCAPSULATED SN38
摘要
The present invention is directed to methods for determining pharmaceutically effective amounts of a liposomal formulation containing SN-38 (LE-SN38) by detecting polymorphisms within a uridine diphosphate glucuronosyltransferase (UGT1A1) gene. In accordance with the inventive method, LE-SN38 is administered at dosages of up to about 35 mg/m2 for individuals having at least one wild-type copy of the UGT1A1 allele and at dosages between about 20 mg/m2 to about 35 mg/m2 for individuals with no wild type UGT1A1 allele, such as dosages between about 20 mg/m2 to about 30 mg/m2.
申请公布号
WO2005117833(A2)
申请公布日期
2005.12.15
申请号
WO2005US19834
申请日期
2005.06.06
申请人
NEOPHARM, INC.;HUSSEY, JAMES;SHERMAN, JEFF;WANASKI, STEPHEN;GATELY, STEPHEN
发明人
HUSSEY, JAMES;SHERMAN, JEFF;WANASKI, STEPHEN;GATELY, STEPHEN