发明名称 Novel pyridine derivative and pyrimidine derivative
摘要 A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R<SUP>1 </SUP>represents C<SUB>1-6 </SUB>alkyl or the like; R<SUP>2 </SUP>and R<SUP>3 </SUP>represent hydrogen; R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, and R<SUP>7 </SUP>may be the same or different and each represents hydrogen, halogen, C<SUB>1-6 </SUB>alkyl or the like; R<SUP>8 </SUP>represents hydrogen or the like; R<SUP>9 </SUP>represents C<SUB>1-6 </SUB>alkyl or the like; V<SUP>1 </SUP>represents oxygen or the like; V<SUP>2 </SUP>represents oxygen or sulfur; W represents -NH- or the like; X represents -CH-, nitrogen or the like; and Y represents oxygen or the like.]
申请公布号 US2005277652(A1) 申请公布日期 2005.12.15
申请号 US20050065631 申请日期 2005.02.25
申请人 EISAI CO., LTD. 发明人 MATSUSHIMA TOMOHIRO;TAKAHASHI KEIKO;FUNASAKA SETSUO;OBAISHI HIROSHI
分类号 A61K31/44;A61K31/4409;A61K31/4427;A61K31/4439;A61K31/444;A61K31/4545;A61K31/496;A61K31/505;A61K31/506;A61K31/5377;A61K31/551;A61P1/18;A61P9/00;A61P11/00;A61P13/08;A61P13/12;A61P15/00;A61P25/00;A61P35/00;A61P35/04;A61P43/00;C07D213/73;C07D213/75;C07D239/46;C07D239/47;C07D239/48;C07D401/12;C07D401/14;C07D403/12;C07D407/12;C07D409/12;C07D413/12;C07D487/08;(IPC1-7):A61K31/506 主分类号 A61K31/44
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