DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KALLIKREIN 10 (KLK10)

摘要

The invention provides a human KLK10 which is associated with the endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, muscle-skeleton disorders, cardiovascular disorders, neurological disorders, urological disorders, respiratory diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK10 as well as pharmaceutical compositions comprising such compounds.