摘要 |
Disclosed are sustained release drug particles suitable for forming sustained release oral pharmaceutical compositions. The sustained release drug particles comprise a drug-ion exchange resin complex and a water-permeable, diffusion barrier surrounding at least a portion of the drug-ion exchange resin complex. The diffusion barrier comprises a film-forming polymer and is free or contains no substantial traces of organic solvent. Also disclosed are oral pharmaceutical compositions, for example, oral suspensions, comprising the sustained release drug particles, a method for the controlled administration of a drug to a patient, and a method for manufacturing the sustained release drug particles. The method of manufacturing involves the use of an aqueous coating composition comprising a water-permeable film-forming polymer such as ethylcellulose. |
申请人 |
MALLINCKRODT INC.;RAMAN, SIVA, N.;CUNNINGHAM, JOHN, P.;LANG, JOHN, F. |
发明人 |
RAMAN, SIVA, N.;CUNNINGHAM, JOHN, P.;LANG, JOHN, F. |