MONOMETHYLPHYTOSPHINGOSINE- POLYETHYLENEGLY COL AND THE COMPOSITION FOR ANTI-CANCER CONTAINING THE SAME

摘要

Disclosed are a monomethylphytosphingosine-polyethyleneglycol (MMPS-PEG) derivative formed by combining monomethylphytosphingosine (MMPS), which is a derivative of sphingolipid, with polyethyleneglycol (PEG) or a pharmaceutically acceptable salt thereof and a composition containing the same. The compound inhibits a growth of tumor xenografted to the mammal, thereby treating or preventing a cancer or a cancer-related disease. In addition, it is possible to inhibit an activity of promoting a cell proliferation, thereby treating or preventing a hyper-proliferative disease such as a cancer and psoriasis. Further, a solubility of the monomethylphytosphingosine is improved and a toxicity thereof influencing on the human body is reduced, thereby remarkably expanding the application ranges thereof.