发明名称 |
PD-1, a receptor for B7-4, and uses therefor |
摘要 |
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response. |
申请公布号 |
AU2005234733(A1) |
申请公布日期 |
2005.12.15 |
申请号 |
AU20050234733 |
申请日期 |
2005.11.21 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;GENETICS INSTITUTE, LLC. |
发明人 |
CLIVE WOOD;GORDON J. FREEMAN |
分类号 |
A61K38/17;A61K39/395;C07K14/705;C07K16/28;C12N15/12;G01N33/50;A61K38/00;A61K39/00;A61K45/00;A61K45/06;A61P1/16;A61P3/10;A61P9/00;A61P9/10;A61P15/06;A61P19/02;A61P21/04;A61P25/00;A61P25/28;A61P29/00;A61P31/06;A61P31/12;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P33/12;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P41/00;C12N15/09;C12Q1/02;G01N33/15;G01N33/566 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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