摘要 |
PROBLEM TO BE SOLVED: To provide a measuring method of the solubility and super solubility of a compound, capable of acquiring solubility data in a case that a crystal is not precipitated, even if a compound solution is cooled. SOLUTION: The measuring method of the solubility and super solubility of the compound includes step (a) of cooling the compound solution known in concentration, while stirring the same to measure the precipitation temperature of the crystal of the compound, step (b) of heating the solution, in which the crystal of the compound is precipitated while stirring the same to measure the completely dissolving the temperature of the crystal and step (c) of adding a predetermined amount of a solvent to the solution, in which the crystal is completely dissolved, not only to prepare a compound solution of lower concentration, but also to calculate the concentration thereof and repeatedly performs steps (a)-(c) for a predetermined number of times. When the crystal of the compound does not precipitate in step (a), in step (d), a seed crystal is added to the compound solution, to confirm the precipitation of the crystal and thereafter, the compound solution is heated under stirring, to measure the perfectly dissolving temperature of the precipitated crystal. COPYRIGHT: (C)2006,JPO&NCIPI
|