METHODS AND APPARATUS FOR LABEL-INDEPENDENT MONITORING OF BIOLOGICAL INTERACTIONS ON SENSITIZED SUBSTRATES
摘要
Sensor interrogation systems based on optical phase changes are configured to quantify analytes. Sensor chips and wells can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on state of polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.
申请公布号
WO2005118143(A2)
申请公布日期
2005.12.15
申请号
WO2005US19691
申请日期
2005.06.03
申请人
ZYOMYX, INC.;INDERMUEHLE, PIERRE;HEIDECKER, MANFRED;FOLLONIER, STEPHANE;WAGNER, PETER
发明人
INDERMUEHLE, PIERRE;HEIDECKER, MANFRED;FOLLONIER, STEPHANE;WAGNER, PETER