发明名称 |
TREATMENT WITH IRINOTECAN (CPT-11) AND AN EGFR-INHIBITOR |
摘要 |
<p>The present invention provides a method for manufacturing a medicament for treating tumors or tumor metastases, characterized in that a therapeutically effective amount of an EGFR kinase inhibitor and irinotecan is used, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and irinotecan combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practising this invention is the compound erlotinib HCl (also known as Tarceva<TM>).</p> |
申请公布号 |
WO2005117877(A1) |
申请公布日期 |
2005.12.15 |
申请号 |
WO2005EP05639 |
申请日期 |
2005.05.25 |
申请人 |
F.HOFFMANN-LA ROCHE AG;CHEN, JIANPING;HIGGINS, BRIAN;KOLINSKY, KENNETH |
发明人 |
CHEN, JIANPING;HIGGINS, BRIAN;KOLINSKY, KENNETH |
分类号 |
A61K31/4706;A61K31/4745;A61K31/498;A61K31/517;A61K31/519;A61K31/5377;A61K39/395;A61K45/06;(IPC1-7):A61K31/474;A61K31/537;A61K31/470;A61P35/00 |
主分类号 |
A61K31/4706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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