FUSION POLYPEPTIDES CAPABLE OF ACTIVATING RECEPTORS

摘要

A fusion polypeptide comprising (A)x-M-(A')Y, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A' may be each be an antibody or fragment derived form an antibody specific for a target receptor. The antibody or fragment may be the same or different ScFv fragments, and/or a ligand or ligand fragment, or derivative, capable of binding the target protein. M is a multimerizing component, and X and Y are independently a number between 1-10.