摘要 |
The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: a) contacting a candidate compound with GPR35, and b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates to use of a GPR35 modulator for the manufacture of a medicament for use as a metabolic stabilizing agent. In addition, the invention relates to a method for increasing GPR35 function, comprising contacting GPR35 with an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein X is O or S; and R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, C1-4 alkoxy, C1-4 alkyl, halogen, hydroxyl, and nitro; wherein said C1-4 alkoxy is optionally substituted with carbo-C1-4-alkoxy or carboxy. |
申请人 |
ARENA PHARMACEUTICALS, INC.;LEONARD, JAMES N.;CHU, ZHI LIANG;UNETT, DAVID J.;GATLIN, JOEL E.;GAIDAROV, IBRAGIM;QIU, JUN;SKINNER, PHILIP J.;BOATMAN, P. DOUGLAS |
发明人 |
LEONARD, JAMES N.;CHU, ZHI LIANG;UNETT, DAVID J.;GATLIN, JOEL E.;GAIDAROV, IBRAGIM;QIU, JUN;SKINNER, PHILIP J.;BOATMAN, P. DOUGLAS |