C-KIT KINASE INHIBITOR

摘要

It was discovered that a compound represented by the general formula (I) shows strong c-Kit kinase inhibitory activity, and it inhibits proliferation of c-Kit kinase activated-cancer cells <Italic>in vitro</Italic> and <Italic>in vivo.</Italic> A novel anticancer agent showing c-Kit kinase inhibitory activity was discovered.
The general formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="39" wi="69" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> (wherein R<Sup>1</Sup> represents methyl etc., R<Sup>2</Sup> represents cyano etc., R<Sup>3</Sup> represents hydrogen etc., R<Sup>4</Sup> represents hydrogen etc.)