发明名称 |
Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens |
摘要 |
An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
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申请公布号 |
US2005271679(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
US20040994204 |
申请日期 |
2004.11.22 |
申请人 |
DADAGLIO GILLES;LECLERC CLAUDE;LADANT DANIEL;VAN DEN EYNDE BENOIT;MOREL SANDRA;BAUCHE CECILE |
发明人 |
DADAGLIO GILLES;LECLERC CLAUDE;LADANT DANIEL;VAN DEN EYNDE BENOIT;MOREL SANDRA;BAUCHE CECILE |
分类号 |
A61K38/16;A61K39/00;A61K39/02;A61K39/385;A61K39/39;A61K47/48;C07H21/04;C12N1/21;C12N9/02;C12N9/88;C12P21/04;(IPC1-7):A61K39/02 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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