发明名称 |
Methods for preparing immunogenic conjugates |
摘要 |
Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazino-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.
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申请公布号 |
US2005271675(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
US20040005851 |
申请日期 |
2004.12.06 |
申请人 |
HEALTH AND HUMAN SERVICES |
发明人 |
SCHNEERSON RACHEL;KUBLER-KIELB JOANNA;MAJADLY FATHY;LEPPLA STEPHEN H.;ROBBINS JOHN B.;LIU DARRELL T.;SHILOAH JOSEPH |
分类号 |
A61K39/00;A61K39/385;C07K14/005;C07K14/195;C07K14/32;(IPC1-7):A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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