| 发明名称 |
Phosphodiesterase 4 inhibitors |
| 摘要 |
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R<SUP>1</SUP>, R<SUP>2</SUP>, and R<SUP>3 </SUP>are as defined herein.
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| 申请公布号 |
US2005272803(A1) |
申请公布日期 |
2005.12.08 |
| 申请号 |
US20050186958 |
申请日期 |
2005.07.22 |
| 申请人 |
RUIPING LIU;DE VIVO MIKE;HESS HANS-JURGEN ERNST;HOPPER ALLEN;KREUSTER ERIK;TEHIM ASHOK |
发明人 |
RUIPING LIU;DE VIVO MIKE;HESS HANS-JURGEN ERNST;HOPPER ALLEN;KREUSTER ERIK;TEHIM ASHOK |
| 分类号 |
C07D207/267;A61K31/4015;A61P9/10;A61P25/00;A61P25/14;A61P25/16;A61P25/24;A61P25/28;A61P29/00;A61P31/16;A61P37/08;A61P43/00;C07D207/26;C07D207/27;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;(IPC1-7):A61K31/402;A61K31/401;C07D47/02;C07D27/12 |
主分类号 |
C07D207/267 |
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