发明名称 |
3-[4-(6-{4,5-DIHYDROISOXAZOL-3-YL}PYRIDIN-3-YL)-3-PHENYL]-5-(1H-1,2,3-TRIAZOL-1-YLMETHYL)-1,3-OXAZOLIDIN-2-ONES AS ANTIBACTERIAL AGENTS |
摘要 |
<p>Compounds of the formula (I): or a pharmaceutically- acceptable salt or pro-drug thereof: wherein R<1> is selected for example from hydrogen, halogen, optionally substituted methyl; R<2> and R<3> are independently selected from hydrogen, fluoro, chloro and trifluoromethyl;R<4> and R<5> are independently selected, for example, from hydrogen, methyl, optionally substituted (2-4C)alkyl , C(O)R<6 >or R<4> and R<5> together with the nitrogen to which they are attached form an optionally substituted 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring or an optionally substituted imidazole ring. Methods for making the compounds of formula (I), compositions containing them and their use as antibacterial agents are also described.</p> |
申请公布号 |
WO2005116021(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
WO2005GB02040 |
申请日期 |
2005.05.24 |
申请人 |
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;CARCANAGUE, DANIEL, ROBERT;GRAVESTOCK, MICHAEL, BARRY |
发明人 |
CARCANAGUE, DANIEL, ROBERT;GRAVESTOCK, MICHAEL, BARRY |
分类号 |
C07D413/14;(IPC1-7):C07D413/14;A61K31/422;A61K31/442;A61P31/04;A61K31/419 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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