| 摘要 |
The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y<SUB>1</SUB>KQYTSIHHGY<SUB>0 </SUB>(SEQ ID NO:2). Y<SUB>1</SUB>KKQYTSIHHGY<SUB>0 </SUB>(SEQ ID NO:3) and Y<SUB>1</SUB>KKKQYTSIHHGY<SUB>0 </SUB>(SEQ ID NO:4), wherein Y<SUB>0 </SUB>is nil or represents V, VV, VVE, VVEV or VVVED and Y<SUB>1 </SUB>represents an internalisation and addressing peptide, derived from the 3rd helix of homeodomains and structually related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.
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