发明名称 |
Verfahren zur Herstellung von optisch activem 1H-3-Aminopyrrolidin und Derivaten davon |
摘要 |
<p>A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino-protected aspartic anhydride represented by the formula (1) with a primary amine represented by the formula R'NH2, subjecting the reaction product to cyclodehydration to obtain an optically active 1-aralkyl-3-(protected amino)pyrrolidine-2,5-dione compound represented by the formula (2), subsequently eliminating the protective group from the 3-position amino group of the compound represented by the formula (2) to obtain an optically active 1-aralkyl-3-aminopyrrolidine-2,5-dione compound represented by the formula (3), reducing the carbonyl groups of the compound represented by the formula (3) to obtain either an optically active 1-aralkyl-3-aminopyrrolidine compound represented by the formula (4) or a salt thereof with a protonic acid, and then subjecting the compound represented by the formula (4) or the salt thereof to hydrogenolysis to obtain an optically active 1H-3-aminopyrrolidine or a protonic acid salt thereof.</p> |
申请公布号 |
DE60114532(D1) |
申请公布日期 |
2005.12.08 |
申请号 |
DE2001614532 |
申请日期 |
2001.08.24 |
申请人 |
MITSUBISHI CHEMICAL CORP., TOKIO/TOKYO |
发明人 |
WATANABE, MICHI;NAKATOU, TAKESHI;TAKEHARA, JUN;KANNO, KAZUAKI;ICHIKAWA, SYUJI |
分类号 |
C07D207/14;C07D207/40;C07D207/416;C07D471/04;C07D477/02;C07D477/20;(IPC1-7):C07D207/14;C07D477/06 |
主分类号 |
C07D207/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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