发明名称 |
METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS |
摘要 |
The invention involves the treatment, prevention, and reduction of immunoinflammatory disorders involving the combination of an agent that increases the signal activity of a glucocorticoid receptor (e.g., glucocorticoid receptor agonist) and an agent that modulates the signaling activity of one or more signaling pathways selected from the NF-kappaB pathway, NFAT pathway, AP-1 pathway, and Elk-1 pathway such that proinflammatory cytokine secretion or production, or any other inflammatory response, is reduced. Further, screening methods are provided for identifying candidate compounds and strategies useful for treating, preventing, or reducing such conditions. |
申请公布号 |
WO2005115455(A2) |
申请公布日期 |
2005.12.08 |
申请号 |
WO2005US17117 |
申请日期 |
2005.05.16 |
申请人 |
COMBINATORX, INCORPORATED;MANIVASAKAM, PALANIYANDI;JOST-PRICE, EDWARD, ROYDON;STAUNTON, JANE;KEITH, CURTIS |
发明人 |
MANIVASAKAM, PALANIYANDI;JOST-PRICE, EDWARD, ROYDON;STAUNTON, JANE;KEITH, CURTIS |
分类号 |
A61K31/192;A61K31/415;A61K31/4745;A61K31/522;A61K31/59;A61K38/13;A61K39/395;A61K45/06;C07K16/18;G01N33/74 |
主分类号 |
A61K31/192 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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