发明名称 |
FORMULATIONS STABLE DURING TRANSITION FROM HYDROPHOBIC VEHICLE TO HYDROPHILIC MEDIUM |
摘要 |
A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid. |
申请公布号 |
WO2005115333(A2) |
申请公布日期 |
2005.12.08 |
申请号 |
WO2005US17914 |
申请日期 |
2005.05.23 |
申请人 |
ALZA CORPORATION;JUNNARKAR, GUNJAN;DESJARDIN, MICHAEL A.;LIU, KUI;LI, ZENGJI |
发明人 |
JUNNARKAR, GUNJAN;DESJARDIN, MICHAEL A.;LIU, KUI;LI, ZENGJI |
分类号 |
A61K9/00;A61K9/14;A61K9/16;A61K31/7024;A61K38/21;A61K47/18 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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地址 |
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