One aspect of the present invention relates to optically pur (S)-amlodipine malate. Another aspect of the present invention relates to (rac)-amlopidine malate. In a preferred embodiment, compound is optically pure (S)-amlodipine L-malate. Another aspect of the present invention relates to a pharmaceutical composition comprising optically pure (S)-amlodipine malate. Another aspect of the present invention relates to a method of preparing optically pure (S)-amlodipine malate, comprising admixing optically pure (S)-amlodipine with malic acid. Another aspect of the present invention relates to the various polymorphic and solvated forms of optically pure (S)-amlodipine malate. In another prefered embodiment the invention relates to polymorphic and solvated forms A-G. The present invention also relates to a method of preparing optically pure (S)-amlodipine malate, comprising combining a salt of optically pure (S)-amlodipine with a malate salt to give optically pure (S)-amlodipine malate. In a preferred embodiment, the malate salt is an optically pure L-malate salt.
申请公布号
WO2005089353(A3)
申请公布日期
2005.12.08
申请号
WO2005US08673
申请日期
2005.03.16
申请人
SEPRACOR INC.;LAUGHLIN, SHARON, M.;BAKALE, ROGER;WILKINSON, HAROLD, SCOTT;ZLOTA, ANDREI
发明人
LAUGHLIN, SHARON, M.;BAKALE, ROGER;WILKINSON, HAROLD, SCOTT;ZLOTA, ANDREI