发明名称 |
SUBSTITUTED THIAZOLEACETIC AS CRTH2 LIGANDS |
摘要 |
<p>Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis; wherein X1 is -S-, -O-, -N=N-. -NR7-, -CR7=CR8-, -CR7=N-, wherein R7 and R8 are independently hydrogen or C1-C3 alkyl; A is a carboxyl group -COOH, or a carboxyl bioisostere; rings Ar<2> and Ar<3> each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; ring B is as defined for Ar<2> and Ar<3>, or an optionally substituted N-pyrrolidinyl, N-piperidinyl or N-azepinyl ring; s is 0 or 1; L1, L2 and L4 are linker radicals as defined in the description; Q1 and Q2 represent substituents as defined in the description.</p> |
申请公布号 |
WO2005116001(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
WO2005EP05882 |
申请日期 |
2005.05.30 |
申请人 |
7TM PHARMA A/S;ULVEN, TROND;FRIMURER, THOMAS;RIST, OEYSTEIN;KOSTENIS, EVI;HOEGBERG, THOMAS;RECEVEUR, JEAN-MARIE;GRIMSTRUP, MARIE |
发明人 |
ULVEN, TROND;FRIMURER, THOMAS;RIST, OEYSTEIN;KOSTENIS, EVI;HOEGBERG, THOMAS;RECEVEUR, JEAN-MARIE;GRIMSTRUP, MARIE |
分类号 |
C07D277/30;C07D417/04;C07D417/06;(IPC1-7):C07D277/30;A61K31/426;A61K31/427;A61P11/06 |
主分类号 |
C07D277/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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