发明名称 |
FUSION GENE OF HEPATITIS B SURFACE ANTIGEN WITH CARBOXYL END HAVING PRES2 IMMUNE DETERMINANT AND THE PROTEIN THEREOF |
摘要 |
<p>The invention provides a fusion gene encoding a new-type Hepatitis B virus surface antigen and the protein thereof. The nucleotide sequence, encoding Hepatitis B virus preS2 antigen (Met1-Gly26) containing B-cell and T-cell epitopes and polymerized albumin binding site, is fused to 3' terminal of Hepatitis B virus surface antigenic main protein S gene, then the expression is carried out in yeast expression system. The expressed products, possessing simultaneously antigenicity of S and preS2, are assembled into virus-like particles with diameter of about 20-35nm and are potential for developing novel Hepatitis B vaccines.</p> |
申请公布号 |
WO2005116218(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
WO2005CN00737 |
申请日期 |
2005.05.27 |
申请人 |
CHENGDU INSTITUTE OF BIOLOGICAL PRODUCTS;TAN, CHANGYAO;JIANG, LIMING;GE, YONGHONG;YUAN, JIN;JIN, OU |
发明人 |
TAN, CHANGYAO;JIANG, LIMING;GE, YONGHONG;YUAN, JIN;JIN, OU |
分类号 |
A61K38/16;A61K39/29;A61P1/16;C07K14/02;C12N15/51;C12N15/62;C12N15/63;(IPC1-7):C12N15/62 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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