METHODS FOR THE PRODUCTION OF SILDENAFIL BASE AND CITRATE SALT
摘要
Provided are processes for the preparation of sildenafil base and the citrate salt sildenafil. Also provided are sildenafil citrate water adduct and a method of preparing pharmaceutical compositions comprising combining the sildenafil citrate and/or sildenafil citrate water adduct with at least one pharmaceutically-acceptable excipient.
申请公布号
WO2005067936(A3)
申请公布日期
2005.12.08
申请号
WO2005US00207
申请日期
2005.01.05
申请人
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;BRAUDE, VIVIANA;ARONHIME, JUDITH;SHABAT, SHALOM