发明名称 |
Supramolecular complexes as photoactivated DNA cleavage agents |
摘要 |
The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging pi-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
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申请公布号 |
US2005272713(A1) |
申请公布日期 |
2005.12.08 |
申请号 |
US20050184840 |
申请日期 |
2005.07.20 |
申请人 |
BREWER KAREN;SWAVEY SHAWN |
发明人 |
BREWER KAREN;SWAVEY SHAWN |
分类号 |
A61K31/555;C07F15/00;(IPC1-7):A61K31/555 |
主分类号 |
A61K31/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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