| 发明名称 |
MATERIALS AND METHODS FOR INHIBITING WIP1 |
| 摘要 |
The invention provides a method of treating cancer in a mammal that expresses the same level or a higher level of Wip1 as compared to a mammal of the same species that does not have cancer, and a method of inhibiting Wip1 in a cell. The invention also provides pharmaceutical compositions comprising a compound selected from the group consisting of Compounds A-N, and a method of making a cancer therapeutic composition. Also provided is a compound selected from the group consisting of Compounds A-N, a method of screening a compound for Wip1-inhibiting activity, and a method of determining the efficacy with which a test compound inhibits Wip1. |
| 申请公布号 |
WO2005089737(A3) |
申请公布日期 |
2005.12.08 |
| 申请号 |
WO2005US08116 |
申请日期 |
2005.03.11 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BULAVIN, DMITRY;BELOVA, GALINA;FORNACE, ALBERT J. JR. |
发明人 |
BULAVIN, DMITRY;BELOVA, GALINA;FORNACE, ALBERT J. JR. |
| 分类号 |
A61K31/00;A61K31/192;A61K31/343;A61K31/4245;A61K31/4365;A61K31/4402;A61K31/4985;A61K31/541;A61K33/24;A61K33/28;A61K33/34;A61K33/38;C07K14/335;C07K14/82;C12N9/16 |
主分类号 |
A61K31/00 |
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