| 摘要 |
The invention relates to a process for preparing quetiapine of formula I by reductive N-alkylation of 11-piperazinodibenzoÄb,fÜÄ1,4Üthiazepine or its salts of formula II with an aldehyde of formula III. The process is carried out in the presence of a metal borohydride (wherein the metal is chosen from the I or II group of the periodic table) in a temperature range from -10 DEG C to 20 DEG C, preferably from 0 DEG C to 5 DEG C. <CHEM> <CHEM> where X<->=Cl<->,Br<->,ClO3<-> <CHEM> (R1=Me,Et,Pr,iPr)
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