| 发明名称 |
Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| 摘要 |
A method for the inhibition of the binding of alpha<SUB>4</SUB>beta<SUB>1 </SUB>integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which alpha<SUB>4</SUB>beta<SUB>1 </SUB>is involved.
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| 申请公布号 |
US6972296(B2) |
申请公布日期 |
2005.12.06 |
| 申请号 |
US20010973142 |
申请日期 |
2001.10.09 |
| 申请人 |
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发明人 |
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| 分类号 |
C07D221/04;A61K31/435;A61K31/44;A61K31/4412;A61K31/4704;A61K31/495;A61K31/50;A61K31/505;A61P1/00;A61P3/10;A61P9/10;A61P11/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;C07D207/416;C07D211/86;C07D213/02;C07D213/62;C07D213/69;C07D213/72;C07D213/75;C07D215/22;C07D215/38;C07D221/16;C07D237/16;C07D237/22;C07D239/28;C07D239/46;C07D239/47;C07D317/46;C07D317/60;C07D401/04;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D409/06;C07D409/12;C07D409/14;C07D413/04;C07D413/06;C07D413/12;C07D417/06;C07D471/04;C07D498/04;C07K14/78;(IPC1-7):A61K31/44;C07D211/72 |
主分类号 |
C07D221/04 |
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代理人 |
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