发明名称 |
Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme |
摘要 |
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
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申请公布号 |
US6972124(B2) |
申请公布日期 |
2005.12.06 |
申请号 |
US20030704365 |
申请日期 |
2003.11.07 |
申请人 |
BIOMARIN PHARMACEUTICALS INC. |
发明人 |
QIN MINMIN;ZECHERLE GARY N.;CHAN WAI-PAN;FITZPATRICK PAUL A.;SWEIDLER STUART;HENSTRAND JOHN M.;WENDT DAN J.;CHEN LIN;STARR CHRISTOPHER M. |
分类号 |
A61K38/00;A61K38/46;A61K48/00;C12N9/16;(IPC1-7):A61K38/46;C12N1/20;C12N5/00;A23J1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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