发明名称 |
Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use |
摘要 |
This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VIP/PACAP-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic.
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申请公布号 |
US6972319(B1) |
申请公布日期 |
2005.12.06 |
申请号 |
US20000671773 |
申请日期 |
2000.09.27 |
申请人 |
BAYER PHARMACEUTICALS CORPORATION |
发明人 |
PAN CLARK;TSUTSUMI MANAMI;SHANAFELT ARMEN B. |
分类号 |
A61K38/00;A61K38/16;C07K14/00;C07K14/47;C07K14/72;(IPC1-7):C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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