| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an anatomically specific bioresorbable implant device for facilitating the healing of voids in bone, cartilage and soft tissue. <P>SOLUTION: A preferred embodiment of using the implant device for facilitating the healing of a human joint lesion includes a cartilage region invested with an alginate microstructure joined with a subchondral bone region invested with a hyaluronan microstructure. The alginate selectively dispersed in the cartilage region enhances an environment for chondrocytes to grow articular cartilage. The hyaluronan selectively dispersed in the subchondral bone region enhances an environment for mesenchymal cells which migrate into that region's macrostructure and which differentiate into osteoblasts. The microstructures can be dispersed at varying concentrations in the regions. A hydrophobic barrier, strategically positioned within the subchondral bone region macrostructure, shields the chondrocytes from the oxygenated blood in subchondral cancellous bone. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
