| 摘要 |
The present invention relates to a vaccine for preventing Mycobacterium tuberculosis infection that contains a polypeptide isolated from Mycobacterium tuberculosis that suppresses the immune response and induces IL-10 in a subject infected with Mycobacterium tuberculosis, and to methods of treating an inflammatory condition in a mammal, vaccinating a mammal against infection by Mycobacterium tuberculosis, and treating a mammal for infection by Mycobacterium tuberculosis, which involve providing a nucleic acid molecule encoding the polypeptide isolated from Mycobacterium tuberculosis that suppresses the immune response and induces IL-10 in a subject infected with Mycobacterium tuberculosis, or the polypeptide itself, and administering the nucleic acid molecule or its encoded polypeptide to a mammal.
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