CANCER TREATMENT WITH INHIBITORS OF COLLAGEN SYNTHESIS

摘要

Compositions and methods are provided for the treatment of tumors with a combination of anti-collagen agents and anti-neoplastic agents. In some embodiments one or more of the anti-collagen agents and anti-neoplastic agents may be provided in a biocompatible polymer matrix. The invention also provides prodrugs comprising anti-collagen and anti-tumor agent conjugates. The inventive compositions and methods can be useful in shrinking or reducing tumor size by abrogating drug diffusion barriers that are often the result of collagenous extracellular matrix of solid tumors.