PEPTIDE ANALOGUES OF GIP FOR TREATMENT OF DIABETES, INSULIN RESISTANCE AND OBESITY
摘要
The present invention provides peptide analogues which are antagonists of gastric inhibitory peptide (GIP). The peptides, based on GIP 1-42 include substitutions and/or modifications which have enhanced resistance to degradation by the enzyme dipeptidyl peptidase IV (DPP IV). The invention also provides a process of N terminally modifying GIP and the use of the peptide analogues for treatment of diabetes.
申请公布号
WO2005082928(A3)
申请公布日期
2005.12.01
申请号
WO2005GB00710
申请日期
2005.02.25
申请人
UNIVERSITY OF ULSTER;GAULT, VICTOR, A.;O'HARTE, FINBARR, PAUL, MARY;FLATT, PETER, RAYMOND;IRWIN, NIGEL;HARRIOT, PATRICK
发明人
GAULT, VICTOR, A.;O'HARTE, FINBARR, PAUL, MARY;FLATT, PETER, RAYMOND;IRWIN, NIGEL;HARRIOT, PATRICK