Isolated OMP106 polypeptide or fragment thereof, vaccine and antigenic composition comprising thereof, isolated DNA, isolated antibody and their use

摘要

Described is an isolated OMP106 polypeptide, which is an outer membrane polypeptide of Moraxella catarrhalis, and has a molecular weight of about 180 kD to about 230 kD as determined in SDS polyacrylamide gel electrophoresis, a peptide fragment of the OMP106 polypeptide, an isolated antibody, a vaccine, an antigenic composition and an isolated DNA. Use of a polypeptide, of a peptide fragment and of an isolated antibody for the manufacture of a medicament for the treatment or prevention of infection with Moraxella catarrhalis is further described.