IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM

摘要

A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is discussed. The synthesis is effected by condensing 7-aminocephalosporanic acid (7-ACA) with 2-(2-chloroacetamidothiazol-4-yl)-2-syn-methoxyiminoacetyl chloride followed by deblocking amino function by thiourea in basic medium. Finally, 7-[2-(2-amino-4-thiazolyl)-2- syn- methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid is converted into sodium salt with sodium-2-ethylhexanoate in solvent mixture of ethyl acetate and methanol in presence of triethylamine in more than 99 % HPLC purity.