Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors

摘要

The invention relates to a formulation containing a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the effect of the nucleotide synthesis inhibitors in a delayed manner; and a nucleotide synthesis inhibitor such as brequinar, mycophenolate mofetile, 2-morpholinoethyl-(E)-6-(1,3-dihydro-4-hydroxy-6- methoxy-7-methyl-3-oxoisobenzofuran-5-yl-4-methyl-4-hexenoate, methotrexate, mizoribine and compounds of formula (I) or (II). Said formulation is suitable for treating immunological diseases or cancer or for transplantations.