The invention relates to a cartilage and bone repair composition comprising a group of human mesenchymal stem cells that are differentiated to the chondro-osteogenic lineage, by means of the amplification thereof with human serum and a transforming growth factor-beta 1 with a molecular domain for binding to collagen I (TGF-ss1-DUC) obtained in eukaryotic expression systems, and a biocompatible material which is absorbed by the cells thus treated. The inventive composition can be employed using implants in the area to be repaired or it can be employed directly by injecting the cells in suspension either at the site of the injury or into the systemic circulation for the widespread distribution thereof.
申请公布号
WO2005112542(A2)
申请公布日期
2005.12.01
申请号
WO2005ES00287
申请日期
2005.05.20
申请人
UNIVERSIDAD DE MALAGA;BECERRA RATIA, JOSE;ANDRADES GOMEZ, JOSE, ANTONIO;CIFUENTES RUEDA, MANUEL;GUERADO PARRA, ENRIQUE