| 发明名称 |
Chimeric adenoviruses for use in cancer treatment |
| 摘要 |
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
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| 申请公布号 |
US2005265973(A1) |
申请公布日期 |
2005.12.01 |
| 申请号 |
US20050136912 |
申请日期 |
2005.05.24 |
| 申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
HARDEN PAUL;HERMISTON TERRY;KUHN IRENE |
| 分类号 |
A61K35/76;A61K48/00;C12N7/00;C12N7/01;C12N7/02;C12N15/861;(IPC1-7):A61K48/00 |
主分类号 |
A61K35/76 |
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