DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NUCLEAR RECEPTOR SUBFAMILY 1, GROUP B, MEMBER 2 (NR1B2)

摘要

The invention provides a human NR1B2 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NR1B2 as well as pharmaceutical compositions comprising such compounds.