| 摘要 |
<p>The present invention relates to a method for the preparation of trilostane from (4alpha,5alpha,17beta)-4,5-epoxyandrost-2-eno(2,3-d)isoxazol-17-o1 as a precursor compound, the method comprising the steps of a) dissolving the precursor compound in methanol; b) treating the precursor compound with a base to effect cleavage of the (2,3-d) isoxazole ring of the precursor compound; c) adding acid and water to the product of step b) to obtain a precipitate of Trilostanc; and d) isolating the precipitate of Trilostane.</p> |
