The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing mediated by the B cell depleting agent. One method of promoting intravascular access is by the use of integrin antagonists. Methods of treating B cell disorders by this approach is also provided.
申请公布号
WO2005113003(A2)
申请公布日期
2005.12.01
申请号
WO2005US12984
申请日期
2005.04.15
申请人
GENENTECH, INC.;CHAN, ANDREW C.;GONG, QIAN;MARTIN, FLAVIUS
