发明名称 |
APPROACHES TO IDENTIFY LESS HARMFUL TOBACCO AND TOBACCO PRODUCTS |
摘要 |
<p>Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX.</p> |
申请公布号 |
WO2005113821(A1) |
申请公布日期 |
2005.12.01 |
申请号 |
WO2005US16941 |
申请日期 |
2005.05.11 |
申请人 |
VECTOR TOBACCO LTD.;NEW YORK MEDICAL UNIVERSITY;ALBINO, ANTHONY;JORGENSEN, ELLEN;TRAGANOS, FRANK;DARZYNKIEWICZ, ZBIGNIEW;JIN, WENDY |
发明人 |
ALBINO, ANTHONY;JORGENSEN, ELLEN;TRAGANOS, FRANK;DARZYNKIEWICZ, ZBIGNIEW;JIN, WENDY |
分类号 |
A01H1/04;C12N9/02;C12N15/82;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A01H1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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