发明名称 |
Methods of treating cancer using IL-21 and monoclonal antibody therapy |
摘要 |
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
|
申请公布号 |
US2005265966(A1) |
申请公布日期 |
2005.12.01 |
申请号 |
US20050134489 |
申请日期 |
2005.05.20 |
申请人 |
KINDSVOGEL WAYNE R;HUGHES STEVEN D;HOLLY RICHARD D;CLEGG CHRISTOPHER H;FOSTER DONALD C;JOHNSON REBECCA A;HEIPEL MARK D;SIVAKUMAR PALLAVUR V |
发明人 |
KINDSVOGEL WAYNE R.;HUGHES STEVEN D.;HOLLY RICHARD D.;CLEGG CHRISTOPHER H.;FOSTER DONALD C.;JOHNSON REBECCA A.;HEIPEL MARK D.;SIVAKUMAR PALLAVUR V. |
分类号 |
A61K38/20;A61K39/395;C07K16/28;C07K16/32;(IPC1-7):A61K38/20 |
主分类号 |
A61K38/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|