DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES
摘要
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
申请公布号
WO2005112885(A2)
申请公布日期
2005.12.01
申请号
WO2005US16689
申请日期
2005.05.12
申请人
BAXTER INTERNATIONAL INC.;SCOTT, TERRENCE, L.;LAFRENIERE, DEBORAH;GIANNOUKAKIS, NICK;BISKER-LIEB, VERED;BROWN, LARRY, L.
发明人
SCOTT, TERRENCE, L.;LAFRENIERE, DEBORAH;GIANNOUKAKIS, NICK;BISKER-LIEB, VERED;BROWN, LARRY, L.